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Aging mice have increased chromosome instability that is exacerbated by elevated Mdm2 expression
Aging is thought to negatively affect multiple cellular processes, including the ability to maintain chromosome stability. Chromosome instability (CIN) is a common property of cancer cells and may be a contributing factor to cellular transformation. The types of DNA aberrations that arise during agi...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161162/ https://www.ncbi.nlm.nih.gov/pubmed/21602883 http://dx.doi.org/10.1038/onc.2011.172 |