ARG098, a novel anti-human Fas antibody, suppresses synovial hyperplasia and prevents cartilage destruction in a severe combined immunodeficient-HuRAg mouse model

BACKGROUND: The anti-human Fas/APO-1/CD95 (Fas) mouse/human chimeric monoclonal IgM antibody ARG098 (ARG098) targets the human Fas molecule. The cytotoxic effects of ARG098 on cells isolated from RA patients, on normal cells in vitro, and on RA synovial tissue and cartilage in vivo using implanted r...

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Detalles Bibliográficos
Autores principales: Odani-Kawabata, Noriko, Takai-Imamura, Miwa, Katsuta, Osamu, Nakamura, Hiroshi, Nishioka, Kusuki, Funahashi, Keiko, Matsubara, Tsukasa, Sasano, Minoru, Aono, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161399/
https://www.ncbi.nlm.nih.gov/pubmed/20875116
http://dx.doi.org/10.1186/1471-2474-11-221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161399/
https://www.ncbi.nlm.nih.gov/pubmed/20875116
http://dx.doi.org/10.1186/1471-2474-11-221

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