Overexpression of the HIF Hydroxylases PHD1, PHD2, PHD3 and FIH Are Individually and Collectively Unfavorable Prognosticators for NSCLC Survival

INTRODUCTION: Hypoxia induced factors (HIFs) are at the heart of the adaptive mechanisms cancer cells must implement for survival. HIFs are regulated by four hydroxylases; Prolyl hydroxylase (PHD)-1,-2,-3 and factor inhibiting HIF (FIH). We aimed to investigate the prognostic impact of these oxygen...

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Detalles Bibliográficos
Autores principales: Andersen, Sigve, Donnem, Tom, Stenvold, Helge, Al-Saad, Samer, Al-Shibli, Khalid, Busund, Lill-Tove, Bremnes, Roy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161788/
https://www.ncbi.nlm.nih.gov/pubmed/21887331
http://dx.doi.org/10.1371/journal.pone.0023847

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161788/
https://www.ncbi.nlm.nih.gov/pubmed/21887331
http://dx.doi.org/10.1371/journal.pone.0023847

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