Tailored ß-Cyclodextrin Blocks the Translocation Pores of Binary Exotoxins from C. Botulinum and C. Perfringens and Protects Cells from Intoxication

BACKGROUND: Clostridium botulinum C2 toxin and Clostridium perfringens iota toxin are binary exotoxins, which ADP-ribosylate actin in the cytosol of mammalian cells and thereby destroy the cytoskeleton. C2 and iota toxin consists of two individual proteins, an enzymatic active (A-) component and a s...

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Detalles Bibliográficos
Autores principales: Nestorovich, Ekaterina M., Karginov, Vladimir A., Popoff, Michel R., Bezrukov, Sergey M., Barth, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161792/
https://www.ncbi.nlm.nih.gov/pubmed/21887348
http://dx.doi.org/10.1371/journal.pone.0023927

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161792/
https://www.ncbi.nlm.nih.gov/pubmed/21887348
http://dx.doi.org/10.1371/journal.pone.0023927

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