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Heterologous production of active ribonuclease inhibitor in Escherichia coli by redox state control and chaperonin coexpression
BACKGROUND: Eukaryotic Ribonuclease inhibitor (RI), belonging to the RNH1 family, is distinguished by unique features - a high sensitivity to oxidation due to the large number of reduced cysteins and a high hydrophobicity, which made most production approaches so far unsuccessful or resulted in very...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161860/ https://www.ncbi.nlm.nih.gov/pubmed/21824411 http://dx.doi.org/10.1186/1475-2859-10-65 |