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A Pre-mRNA–Associating Factor Links Endogenous siRNAs to Chromatin Regulation

In plants and fungi, small RNAs silence gene expression in the nucleus by establishing repressive chromatin states. The role of endogenous small RNAs in metazoan nuclei is largely unknown. Here we show that endogenous small interfering RNAs (endo-siRNAs) direct Histone H3 Lysine 9 methylation (H3K9m...

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Detalles Bibliográficos
Autores principales: Burkhart, Kirk B., Guang, Shouhong, Buckley, Bethany A., Wong, Lily, Bochner, Aaron F., Kennedy, Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161925/
https://www.ncbi.nlm.nih.gov/pubmed/21901112
http://dx.doi.org/10.1371/journal.pgen.1002249