Protein C Mutation (A267T) Results in ER Retention and Unfolded Protein Response Activation

BACKGROUND: Protein C (PC) deficiency is associated with a high risk of venous thrombosis. Recently, we identified the PC-A267T mutation in a patient with PC deficiency and revealed by in vitro studies decreased intracellular and secreted levels of the mutant. The aim of the present study was to cha...

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Detalles Bibliográficos
Autores principales: Tjeldhorn, Lena, Iversen, Nina, Sandvig, Kirsten, Bergan, Jonas, Sandset, Per Morten, Skretting, Grethe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162024/
https://www.ncbi.nlm.nih.gov/pubmed/21901152
http://dx.doi.org/10.1371/journal.pone.0024009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162024/
https://www.ncbi.nlm.nih.gov/pubmed/21901152
http://dx.doi.org/10.1371/journal.pone.0024009

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