The Immunoglobulin Heavy Chain Gene 3’ Enhancers Induce Bcl2 Deregulation and Lymphomagenesis in Murine B Cells

Human follicular B-cell lymphoma is associated with the t(14;18) chromosomal translocation that juxtaposes the Bcl2 proto-oncogene with the immunoglobulin heavy chain (Igh) locus, resulting in the deregulated expression of Bcl2. Our previous studies have shown that the Igh 3’ enhancers deregulate Bc...

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Detalles Bibliográficos
Autores principales: Xiang, Hong, Noonan, Emily J., Wang, Jinghong, Duan, Hong, Ma, Lawrence, Michie, Sara, Boxer, Linda M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162065/
https://www.ncbi.nlm.nih.gov/pubmed/21606958
http://dx.doi.org/10.1038/leu.2011.115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162065/
https://www.ncbi.nlm.nih.gov/pubmed/21606958
http://dx.doi.org/10.1038/leu.2011.115

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