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Interleukin-2 is Present in Human Blood Vessels and Released in Biologically Active Form by Heparanase
Interleukin-2 is a multifaceted cytokine with both immunostimulatory and immunosuppressive properties. Our laboratory recently demonstrated that the availability of IL-2 is regulated, in part, by association with perlecan, a heparan sulfate proteoglycan. Given the abundance of perlecan in blood vess...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162067/ https://www.ncbi.nlm.nih.gov/pubmed/21606942 http://dx.doi.org/10.1038/icb.2011.45 |
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author | Miller, John D. Clabaugh, Suzanne E. Smith, Deandra R. Stevens, R. B. Wrenshall, Lucile E. |
author_facet | Miller, John D. Clabaugh, Suzanne E. Smith, Deandra R. Stevens, R. B. Wrenshall, Lucile E. |
author_sort | Miller, John D. |
collection | PubMed |
description | Interleukin-2 is a multifaceted cytokine with both immunostimulatory and immunosuppressive properties. Our laboratory recently demonstrated that the availability of IL-2 is regulated, in part, by association with perlecan, a heparan sulfate proteoglycan. Given the abundance of perlecan in blood vessels, we asked whether IL-2 is present in vessel walls. Our results indicate that IL-2 is associated with endothelial and smooth muscle cells within the human arterial wall. This IL-2 is released by heparanase, and promotes the proliferation of an IL-2 dependent cell line. Given the presence of IL-2 in human arteries, we asked whether the large vessels of IL-2 deficient mice were normal. The aortas of IL-2 deficient mice exhibited a loss of smooth muscle cells, suggesting that IL-2 may contribute to their survival. In their entirety, these results suggest a here-to-fore unrecognized role of IL-2 in vascular biology, and have significant implications for both the immune and cardiovascular systems. |
format | Online Article Text |
id | pubmed-3162067 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
record_format | MEDLINE/PubMed |
spelling | pubmed-31620672012-08-01 Interleukin-2 is Present in Human Blood Vessels and Released in Biologically Active Form by Heparanase Miller, John D. Clabaugh, Suzanne E. Smith, Deandra R. Stevens, R. B. Wrenshall, Lucile E. Immunol Cell Biol Article Interleukin-2 is a multifaceted cytokine with both immunostimulatory and immunosuppressive properties. Our laboratory recently demonstrated that the availability of IL-2 is regulated, in part, by association with perlecan, a heparan sulfate proteoglycan. Given the abundance of perlecan in blood vessels, we asked whether IL-2 is present in vessel walls. Our results indicate that IL-2 is associated with endothelial and smooth muscle cells within the human arterial wall. This IL-2 is released by heparanase, and promotes the proliferation of an IL-2 dependent cell line. Given the presence of IL-2 in human arteries, we asked whether the large vessels of IL-2 deficient mice were normal. The aortas of IL-2 deficient mice exhibited a loss of smooth muscle cells, suggesting that IL-2 may contribute to their survival. In their entirety, these results suggest a here-to-fore unrecognized role of IL-2 in vascular biology, and have significant implications for both the immune and cardiovascular systems. 2011-05-24 2012-02 /pmc/articles/PMC3162067/ /pubmed/21606942 http://dx.doi.org/10.1038/icb.2011.45 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Miller, John D. Clabaugh, Suzanne E. Smith, Deandra R. Stevens, R. B. Wrenshall, Lucile E. Interleukin-2 is Present in Human Blood Vessels and Released in Biologically Active Form by Heparanase |
title | Interleukin-2 is Present in Human Blood Vessels and Released in Biologically Active Form by Heparanase |
title_full | Interleukin-2 is Present in Human Blood Vessels and Released in Biologically Active Form by Heparanase |
title_fullStr | Interleukin-2 is Present in Human Blood Vessels and Released in Biologically Active Form by Heparanase |
title_full_unstemmed | Interleukin-2 is Present in Human Blood Vessels and Released in Biologically Active Form by Heparanase |
title_short | Interleukin-2 is Present in Human Blood Vessels and Released in Biologically Active Form by Heparanase |
title_sort | interleukin-2 is present in human blood vessels and released in biologically active form by heparanase |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162067/ https://www.ncbi.nlm.nih.gov/pubmed/21606942 http://dx.doi.org/10.1038/icb.2011.45 |
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