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Regulation of miR-146a by RelA/NFkB and p53 in STHdh(Q111)/Hdh(Q111) Cells, a Cell Model of Huntington's Disease

Huntington's disease (HD) is caused by the expansion of N-terminal polymorphic poly Q stretch of the protein huntingtin (HTT). Deregulated microRNAs and loss of function of transcription factors recruited to mutant HTT aggregates could cause characteristic transcriptional deregulation associate...

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Detalles Bibliográficos
Autores principales: Ghose, Jayeeta, Sinha, Mithun, Das, Eashita, Jana, Nihar R., Bhattacharyya, Nitai P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162608/
https://www.ncbi.nlm.nih.gov/pubmed/21887328
http://dx.doi.org/10.1371/journal.pone.0023837