A Simple Bias Correction in Linear Regression for Quantitative Trait Association Under Two-Tail Extreme Selection

Selective genotyping can increase power in quantitative trait association. One example of selective genotyping is two-tail extreme selection, but simple linear regression analysis gives a biased genetic effect estimate. Here, we present a simple correction for the bias.

Detalles Bibliográficos
Autores principales: Kwan, Johnny S. H., Kung, Annie W. C., Sham, Pak C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162965/
https://www.ncbi.nlm.nih.gov/pubmed/21626281
http://dx.doi.org/10.1007/s10519-011-9475-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162965/
https://www.ncbi.nlm.nih.gov/pubmed/21626281
http://dx.doi.org/10.1007/s10519-011-9475-0

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