A Simple Bias Correction in Linear Regression for Quantitative Trait Association Under Two-Tail Extreme Selection

Selective genotyping can increase power in quantitative trait association. One example of selective genotyping is two-tail extreme selection, but simple linear regression analysis gives a biased genetic effect estimate. Here, we present a simple correction for the bias.

Detalles Bibliográficos
Autores principales: Kwan, Johnny S. H., Kung, Annie W. C., Sham, Pak C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162965/
https://www.ncbi.nlm.nih.gov/pubmed/21626281
http://dx.doi.org/10.1007/s10519-011-9475-0
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author Kwan, Johnny S. H.
Kung, Annie W. C.
Sham, Pak C.
author_facet Kwan, Johnny S. H.
Kung, Annie W. C.
Sham, Pak C.
author_sort Kwan, Johnny S. H.
collection PubMed
description Selective genotyping can increase power in quantitative trait association. One example of selective genotyping is two-tail extreme selection, but simple linear regression analysis gives a biased genetic effect estimate. Here, we present a simple correction for the bias.
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spelling pubmed-31629652011-09-26 A Simple Bias Correction in Linear Regression for Quantitative Trait Association Under Two-Tail Extreme Selection Kwan, Johnny S. H. Kung, Annie W. C. Sham, Pak C. Behav Genet Article Selective genotyping can increase power in quantitative trait association. One example of selective genotyping is two-tail extreme selection, but simple linear regression analysis gives a biased genetic effect estimate. Here, we present a simple correction for the bias. Springer US 2011-05-29 2011 /pmc/articles/PMC3162965/ /pubmed/21626281 http://dx.doi.org/10.1007/s10519-011-9475-0 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Article
Kwan, Johnny S. H.
Kung, Annie W. C.
Sham, Pak C.
A Simple Bias Correction in Linear Regression for Quantitative Trait Association Under Two-Tail Extreme Selection
title A Simple Bias Correction in Linear Regression for Quantitative Trait Association Under Two-Tail Extreme Selection
title_full A Simple Bias Correction in Linear Regression for Quantitative Trait Association Under Two-Tail Extreme Selection
title_fullStr A Simple Bias Correction in Linear Regression for Quantitative Trait Association Under Two-Tail Extreme Selection
title_full_unstemmed A Simple Bias Correction in Linear Regression for Quantitative Trait Association Under Two-Tail Extreme Selection
title_short A Simple Bias Correction in Linear Regression for Quantitative Trait Association Under Two-Tail Extreme Selection
title_sort simple bias correction in linear regression for quantitative trait association under two-tail extreme selection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162965/
https://www.ncbi.nlm.nih.gov/pubmed/21626281
http://dx.doi.org/10.1007/s10519-011-9475-0
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