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Selection for Translation Efficiency on Synonymous Polymorphisms in Recent Human Evolution

Synonymous mutations are considered to be “silent” as they do not affect protein sequence. However, different silent codons have different translation efficiency (TE), which raises the question to what extent such mutations are really neutral. We perform the first genome-wide study of natural select...

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Detalles Bibliográficos
Autores principales: Waldman, Yedael Y., Tuller, Tamir, Keinan, Alon, Ruppin, Eytan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163469/
https://www.ncbi.nlm.nih.gov/pubmed/21803767
http://dx.doi.org/10.1093/gbe/evr076