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Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development

BACKGROUND: Plasmodium falciparum contains three genes encoding potential glutamate dehydrogenases. The protein encoded by gdha has previously been biochemically and structurally characterized. It was suggested that it is important for the supply of reducing equivalents during intra-erythrocytic dev...

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Detalles Bibliográficos
Autores principales: Storm, Janet, Perner, Jan, Aparicio, Isabela, Patzewitz, Eva-Maria, Olszewski, Kellen, Llinas, Manuel, Engel, Paul C, Müller, Sylke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163627/
https://www.ncbi.nlm.nih.gov/pubmed/21756354
http://dx.doi.org/10.1186/1475-2875-10-193