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Repression of human activation induced cytidine deaminase by miR-93 and miR-155

BACKGROUND: Activation Induced cytidine Deaminase (AID) targets the immunoglobulin genes of activated B cells, where it converts cytidine to uracil to induce mutagenesis and recombination. While essential for immunoglobulin gene diversification, AID misregulation can result in genomic instability an...

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Detalles Bibliográficos
Autores principales: Borchert, Glen M, Holton, Nathaniel W, Larson, Erik D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163633/
https://www.ncbi.nlm.nih.gov/pubmed/21831295
http://dx.doi.org/10.1186/1471-2407-11-347