Mechanically induced experimental knee osteoarthritis benefits from anti-inflammatory and immunomodulatory properties of simvastatin via inhibition of matrix metalloproteinase-3

BACKGROUND: We investigated the anti-inflammatory and immunomodulatory effect of simvastatin on articular cartilage via the inhibition of matrix metalloproteinase-3 (MMP-3), a matrix-degrading enzyme, in a mechanically induced experimental osteoarthritis (OA) animal model. MATERIALS AND METHODS: Twe...

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Detalles Bibliográficos
Autores principales: Aktas, Erdem, Sener, Ertugrul, Gocun, Pınar Uyar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163794/
https://www.ncbi.nlm.nih.gov/pubmed/21863259
http://dx.doi.org/10.1007/s10195-011-0154-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163794/
https://www.ncbi.nlm.nih.gov/pubmed/21863259
http://dx.doi.org/10.1007/s10195-011-0154-y

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