C-Terminal Substitution of MDM2 Interacting Peptides Modulates Binding Affinity by Distinctive Mechanisms

The complex between the proteins MDM2 and p53 is a promising drug target for cancer therapy. The residues 19–26 of p53 have been biochemically and structurally demonstrated to be a most critical region to maintain the association of MDM2 and p53. Variation of the amino acid sequence in this range ob...

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Detalles Bibliográficos
Autores principales: Brown, Christopher J., Dastidar, Shubhra G., Quah, Soo T., Lim, Annie, Chia, Brian, Verma, Chandra S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164098/
https://www.ncbi.nlm.nih.gov/pubmed/21904608
http://dx.doi.org/10.1371/journal.pone.0024122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164098/
https://www.ncbi.nlm.nih.gov/pubmed/21904608
http://dx.doi.org/10.1371/journal.pone.0024122

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