The K(+) Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients

BACKGROUND: The identification of strategies to improve mutant CFTR function remains a key priority in the development of new treatments for cystic fibrosis (CF). Previous studies demonstrated that the K(+) channel opener 1-ethyl-2-benzimidazolone (1-EBIO) potentiates CFTR-mediated Cl(−) secretion i...

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Detalles Bibliográficos
Autores principales: Roth, Eva K., Hirtz, Stephanie, Duerr, Julia, Wenning, Daniel, Eichler, Irmgard, Seydewitz, Hans H., Amaral, Margarida D., Mall, Marcus A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164200/
https://www.ncbi.nlm.nih.gov/pubmed/21909392
http://dx.doi.org/10.1371/journal.pone.0024445

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164200/
https://www.ncbi.nlm.nih.gov/pubmed/21909392
http://dx.doi.org/10.1371/journal.pone.0024445

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