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Feedback inhibition of L1 and alu retrotransposition through altered double strand break repair kinetics
BACKGROUND: Cells adapt to various chronic toxic exposures in a multitude of ways to minimize further damage and maximize their growth potential. Expression of L1 elements in the human genome can be greatly deleterious to cells, generating numerous double strand breaks (DSBs). Cells have been report...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164224/ https://www.ncbi.nlm.nih.gov/pubmed/20979631 http://dx.doi.org/10.1186/1759-8753-1-22 |