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The nuclear envelope localization of DYT1 dystonia torsinA-ΔE requires the SUN1 LINC complex component

BACKGROUND: DYT1 dystonia is an autosomal dominant neurological condition caused by a mutation that removes a single glutamic acid residue (ΔE) from the torsinA (torA) AAA+ protein. TorA appears to possess a nuclear envelope (NE) localized activity that requires Lamina-Associated-Polypeptide 1 (LAP1...

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Detalles Bibliográficos
Autores principales:	Jungwirth, Michael T, Kumar, Dhivya, Jeong, Danielle Y, Goodchild, Rose E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164226/ https://www.ncbi.nlm.nih.gov/pubmed/21627841 http://dx.doi.org/10.1186/1471-2121-12-24

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