Reduction of mutant huntingtin accumulation and toxicity by lysosomal cathepsins D and B in neurons

BACKGROUND: Huntington's disease is caused by aggregation of mutant huntingtin (mHtt) protein containing more than a 36 polyQ repeat. Upregulation of macroautophagy was suggested as a neuroprotective strategy to degrade mutant huntingtin. However, macroautophagy initiation has been shown to be...

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Detalles Bibliográficos
Autores principales: Liang, Qiuli, Ouyang, Xiaosen, Schneider, Lonnie, Zhang, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164227/
https://www.ncbi.nlm.nih.gov/pubmed/21631942
http://dx.doi.org/10.1186/1750-1326-6-37

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164227/
https://www.ncbi.nlm.nih.gov/pubmed/21631942
http://dx.doi.org/10.1186/1750-1326-6-37

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