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Reduction of mutant huntingtin accumulation and toxicity by lysosomal cathepsins D and B in neurons
BACKGROUND: Huntington's disease is caused by aggregation of mutant huntingtin (mHtt) protein containing more than a 36 polyQ repeat. Upregulation of macroautophagy was suggested as a neuroprotective strategy to degrade mutant huntingtin. However, macroautophagy initiation has been shown to be...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164227/ https://www.ncbi.nlm.nih.gov/pubmed/21631942 http://dx.doi.org/10.1186/1750-1326-6-37 |