Neuroprotective role of PrP(C) against kainate-induced epileptic seizures and cell death depends on the modulation of JNK3 activation by GluR6/7–PSD-95 binding

Cellular prion protein (PrP(C)) is a glycosyl-phosphatidylinositol–anchored glycoprotein. When mutated or misfolded, the pathogenic form (PrP(SC)) induces transmissible spongiform encephalopathies. In contrast, PrP(C) has a number of physiological functions in several neural processes. Several lines...

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Detalles Bibliográficos
Autores principales: Carulla, Patricia, Bribián, Ana, Rangel, Alejandra, Gavín, Rosalina, Ferrer, Isidro, Caelles, Carme, del Río, José Antonio, Llorens, Franc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2011
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164453/
https://www.ncbi.nlm.nih.gov/pubmed/21757544
http://dx.doi.org/10.1091/mbc.E11-04-0321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164453/
https://www.ncbi.nlm.nih.gov/pubmed/21757544
http://dx.doi.org/10.1091/mbc.E11-04-0321

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