Cargando…

Role of epithelial integrin-linked kinase in promoting intestinal inflammation: effects on CCL2, fibronectin and the T cell repertoire

BACKGROUND: The role of integrin signaling in mucosal inflammation is presently unknown. Hence, we aimed to investigate the role of epithelial-derived integrin-linked kinase (ILK), a critical integrin signaling intermediary molecule, in colonic inflammation. METHODS: Conditional intestinal epithelia...

Descripción completa

Detalles Bibliográficos
Autores principales:	Assi, Kiran, Patterson, Scott, Dedhar, Shoukat, Owen, David, Levings, Megan, Salh, Baljinder
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164617/ https://www.ncbi.nlm.nih.gov/pubmed/21806815 http://dx.doi.org/10.1186/1471-2172-12-42

Ejemplares similares

Integrin-Linked Kinase links Dynactin-1/Dynactin-2 with cortical Integrin receptors to orient the mitotic spindle relative to the substratum
por: Morris, Edward James, et al.
Publicado: (2015)

Requirement of epithelial integrin-linked kinase for facilitation of Citrobacter rodentium-induced colitis
por: Assi, Kiran, et al.
Publicado: (2013)

Characterisation of integrin-linked kinase signalling in sporadic human colon cancer
por: Marotta, A, et al.
Publicado: (2003)

Regulation of Mitotic Cytoskeleton Dynamics and Cytokinesis by Integrin-Linked Kinase in Retinoblastoma Cells
por: Sikkema, William K. A., et al.
Publicado: (2014)

New Perspectives on the Role of Integrin-Linked Kinase (ILK) Signaling in Cancer Metastasis
por: McDonald, Paul C., et al.
Publicado: (2022)

Integrin-Linked Kinase Regulates Interphase and Mitotic Microtubule Dynamics
por: Lim, Simin, et al.
Publicado: (2013)

Integrin-linked kinase (ILK) and its interactors: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes
por: Wu, Chuanyue, et al.
Publicado: (2001)

Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase
por: Serrano, Isabel, et al.
Publicado: (2013)

Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization
por: Fielding, Andrew B., et al.
Publicado: (2008)

Insulin attenuates apoptosis in neuronal cells by an integrin-linked kinase-dependent mechanism
por: Tan, Jacqueline, et al.
Publicado: (2019)

Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes
por: Terpstra, Leonieke, et al.
Publicado: (2003)

A dual role for integrin-linked kinase in platelets: regulating integrin function and α-granule secretion
por: Tucker, Katherine L., et al.
Publicado: (2008)

Integrin-linked kinase functions as a downstream signal of platelet-derived growth factor to regulate actin polymerization and vascular smooth muscle cell migration
por: Esfandiarei, Mitra, et al.
Publicado: (2010)

Cooperative signaling between Wnt1 and integrin-linked kinase induces accelerated breast tumor development
por: Oloumi, Arusha, et al.
Publicado: (2010)

Integrin-linked kinase regulates migration and proliferation of human intestinal cells under a fibronectin-dependent mechanism
por: Gagné, David, et al.
Publicado: (2010)

Integrin-Linked Kinase Is a Functional Mn(2+)-Dependent Protein Kinase that Regulates Glycogen Synthase Kinase-3β (GSK-3β) Phosphorylation
por: Maydan, Mykola, et al.
Publicado: (2010)

Urokinase-type Plasminogen Activator (uPA) is Inhibited with QLT0267 a Small Molecule Targeting Integrin-linked Kinase (ILK)
por: Santos, Nancy Dos, et al.
Publicado: (2007)

P38MAP kinase, but not phosphoinositol-3 kinase, signal downstream of glutamine-mediated fibronectin-integrin signaling after intestinal injury
por: Niederlechner, Stefanie, et al.
Publicado: (2013)

Expression of fibronectin, fibronectin isoforms and integrin receptors in melanocytic lesions.
por: Natali, P. G., et al.
Publicado: (1995)

Fibronectin is a good catch for integrin
por: Short, Ben
Publicado: (2009)

Autoimmune cholangitis mimicking a klatskin tumor: a case report
por: Shingina, Alexandra, et al.
Publicado: (2011)

The epithelial–mesenchymal transition: new insights in signaling, development, and disease
por: Lee, Jonathan M., et al.
Publicado: (2006)

Beta 1 integrin-dependent and -independent polymerization of fibronectin
Publicado: (1996)

Tissue Transglutaminase Is an Integrin-Binding Adhesion Coreceptor for Fibronectin
por: Akimov, Sergey S., et al.
Publicado: (2000)

QLT0267, a small molecule inhibitor targeting integrin-linked kinase (ILK), and docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in P-AKT levels, altered F-actin architecture and improved treatment outcomes in an orthotopic breast cancer model
por: Kalra, Jessica, et al.
Publicado: (2009)

Integrin α5/fibronectin1 and focal adhesion kinase are required for lens fiber morphogenesis in zebrafish
por: Hayes, Julie M., et al.
Publicado: (2012)

Emphysematous cystitis as a potential marker of severe Crohn's disease
por: Hasan, S. M. Mahmudul, et al.
Publicado: (2022)

The alpha v beta 1 integrin functions as a fibronectin receptor but does not support fibronectin matrix assembly and cell migration on fibronectin
Publicado: (1993)

Interplay of Carbonic Anhydrase IX With Amino Acid and Acid/Base Transporters in the Hypoxic Tumor Microenvironment
por: Venkateswaran, Geetha, et al.
Publicado: (2020)

Participation of Integrin α5β1 in the Fibronectin-Mediated Adherence of Enteroaggregative Escherichia coli to Intestinal Cells
por: Izquierdo, Mariana, et al.
Publicado: (2014)

Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators
por: Kadler, Karl E, et al.
Publicado: (2008)

Tumor Angiogenesis in the Absence of Fibronectin or Its Cognate Integrin Receptors
por: Murphy, Patrick A., et al.
Publicado: (2015)

Targeting hypoxic tumour cells to overcome metastasis
por: Bennewith, Kevin L, et al.
Publicado: (2011)

Carving out its niche: A role for carbonic anhydrase IX in pre-metastatic niche development
por: Chafe, Shawn C, et al.
Publicado: (2015)

Stat3 in mitosis: A new role in clustering excess centrosomes
por: Morris, Edward J., et al.
Publicado: (2017)

β1 integrin, ILK and mTOR regulate collagen synthesis in mechanically loaded tendon cells
por: Mousavizadeh, Rouhollah, et al.
Publicado: (2020)

Dynamic cytoskeleton-integrin associations induced by cell binding to immobilized fibronectin
Publicado: (1989)

Multiplicity of fibronectin-binding alpha V integrin receptors in colorectal cancer.
por: Agrez, M. V., et al.
Publicado: (1996)

Interaction between Fibronectin and β1 Integrin Is Essential for Tooth Development
por: Saito, Kan, et al.
Publicado: (2015)

Fibronectin Regulation of Integrin B1 and SLUG in Circulating Tumor Cells
por: Huaman, Jeannette, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_3d6a3kh0qjcegglagmebhahfqu