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Chlamydia trachomatis Co-opts GBF1 and CERT to Acquire Host Sphingomyelin for Distinct Roles during Intracellular Development

The obligate intracellular pathogen Chlamydia trachomatis replicates within a membrane-bound inclusion that acquires host sphingomyelin (SM), a process that is essential for replication as well as inclusion biogenesis. Previous studies demonstrate that SM is acquired by a Brefeldin A (BFA)-sensitive...

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Detalles Bibliográficos
Autores principales: Elwell, Cherilyn A., Jiang, Shaobo, Kim, Jung Hwa, Lee, Albert, Wittmann, Torsten, Hanada, Kentaro, Melancon, Paul, Engel, Joanne N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164637/
https://www.ncbi.nlm.nih.gov/pubmed/21909260
http://dx.doi.org/10.1371/journal.ppat.1002198