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Significant Effects of Antiretroviral Therapy on Global Gene Expression in Brain Tissues of Patients with HIV-1-Associated Neurocognitive Disorders

Antiretroviral therapy (ART) has reduced morbidity and mortality in HIV-1 infection; however HIV-1-associated neurocognitive disorders (HAND) persist despite treatment. The reasons for the limited efficacy of ART in the brain are unknown. Here we used functional genomics to determine ART effectivene...

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Detalles Bibliográficos
Autores principales: Borjabad, Alejandra, Morgello, Susan, Chao, Wei, Kim, Seon-Young, Brooks, Andrew I., Murray, Jacinta, Potash, Mary Jane, Volsky, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164642/
https://www.ncbi.nlm.nih.gov/pubmed/21909266
http://dx.doi.org/10.1371/journal.ppat.1002213