Lys98 Substitution in Human AP Endonuclease 1 Affects the Kinetic Mechanism of Enzyme Action in Base Excision and Nucleotide Incision Repair Pathways

Human apurinic/apyrimidinic endonuclease 1 (APE1) is a key enzyme in the base excision repair (BER) and nucleotide incision repair (NIR) pathways. We recently analyzed the conformational dynamics and kinetic mechanism of wild-type (wt) protein, in a stopped-flow fluorescence study. In this study, we...

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Detalles Bibliográficos
Autores principales: Timofeyeva, Nadezhda A., Koval, Vladimir V., Ishchenko, Alexander A., Saparbaev, Murat K., Fedorova, Olga S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164677/
https://www.ncbi.nlm.nih.gov/pubmed/21912662
http://dx.doi.org/10.1371/journal.pone.0024063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164677/
https://www.ncbi.nlm.nih.gov/pubmed/21912662
http://dx.doi.org/10.1371/journal.pone.0024063

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