Germline Genetic Variants Disturbing the Let-7/LIN28 Double-Negative Feedback Loop Alter Breast Cancer Susceptibility

Previous studies have shown that let-7 can repress the post-transcriptional translation of LIN28, and LIN28 in turn could block the maturation of let-7, forming a double-negative feedback loop. In this study, we investigated the effect of germline genetic variants on regulation of the homeostasis of...

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Detalles Bibliográficos
Autores principales: Chen, Ao-Xiang, Yu, Ke-Da, Fan, Lei, Li, Ji-Yu, Yang, Chen, Huang, A-Ji, Shao, Zhi-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164678/
https://www.ncbi.nlm.nih.gov/pubmed/21912531
http://dx.doi.org/10.1371/journal.pgen.1002259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164678/
https://www.ncbi.nlm.nih.gov/pubmed/21912531
http://dx.doi.org/10.1371/journal.pgen.1002259

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