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Drosophila IAP1-Mediated Ubiquitylation Controls Activation of the Initiator Caspase DRONC Independent of Protein Degradation

Ubiquitylation targets proteins for proteasome-mediated degradation and plays important roles in many biological processes including apoptosis. However, non-proteolytic functions of ubiquitylation are also known. In Drosophila, the inhibitor of apoptosis protein 1 (DIAP1) is known to ubiquitylate th...

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Detalles Bibliográficos
Autores principales: Lee, Tom V., Fan, Yun, Wang, Shiuan, Srivastava, Mayank, Broemer, Meike, Meier, Pascal, Bergmann, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164697/
https://www.ncbi.nlm.nih.gov/pubmed/21909282
http://dx.doi.org/10.1371/journal.pgen.1002261