Presenilin 1 Regulates Homeostatic Synaptic Scaling Through Akt Signaling

Neurons in vivo and in vitro adapt to long-lasting changes in network activity by adjusting their synaptic strengths to stabilize firing rates. Here we show that homeostatic scaling of excitatory synapses is impaired in mouse hippocampal neurons lacking presenilin 1 (PS1(−/−)) or expressing a famili...

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Detalles Bibliográficos
Autores principales: Pratt, Kara G., Zimmerman, Eric C., Cook, David G., Sullivan, Jane M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164917/
https://www.ncbi.nlm.nih.gov/pubmed/21841774
http://dx.doi.org/10.1038/nn.2893

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164917/
https://www.ncbi.nlm.nih.gov/pubmed/21841774
http://dx.doi.org/10.1038/nn.2893

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