Presenilin 1 Regulates Homeostatic Synaptic Scaling Through Akt Signaling

Neurons in vivo and in vitro adapt to long-lasting changes in network activity by adjusting their synaptic strengths to stabilize firing rates. Here we show that homeostatic scaling of excitatory synapses is impaired in mouse hippocampal neurons lacking presenilin 1 (PS1(−/−)) or expressing a famili...

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Detalles Bibliográficos
Autores principales: Pratt, Kara G., Zimmerman, Eric C., Cook, David G., Sullivan, Jane M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164917/
https://www.ncbi.nlm.nih.gov/pubmed/21841774
http://dx.doi.org/10.1038/nn.2893
Descripción
Sumario:Neurons in vivo and in vitro adapt to long-lasting changes in network activity by adjusting their synaptic strengths to stabilize firing rates. Here we show that homeostatic scaling of excitatory synapses is impaired in mouse hippocampal neurons lacking presenilin 1 (PS1(−/−)) or expressing a familial Alzheimer’s disease-linked PS1 mutation (PS1(M146V)). These findings suggest that deficits in synaptic homeostasis may contribute to brain dysfunction in Alzheimer’s disease.

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