Presenilin 1 Regulates Homeostatic Synaptic Scaling Through Akt Signaling

Neurons in vivo and in vitro adapt to long-lasting changes in network activity by adjusting their synaptic strengths to stabilize firing rates. Here we show that homeostatic scaling of excitatory synapses is impaired in mouse hippocampal neurons lacking presenilin 1 (PS1(−/−)) or expressing a famili...

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Autores principales: Pratt, Kara G., Zimmerman, Eric C., Cook, David G., Sullivan, Jane M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164917/
https://www.ncbi.nlm.nih.gov/pubmed/21841774
http://dx.doi.org/10.1038/nn.2893
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author Pratt, Kara G.
Zimmerman, Eric C.
Cook, David G.
Sullivan, Jane M.
author_facet Pratt, Kara G.
Zimmerman, Eric C.
Cook, David G.
Sullivan, Jane M.
author_sort Pratt, Kara G.
collection PubMed
description Neurons in vivo and in vitro adapt to long-lasting changes in network activity by adjusting their synaptic strengths to stabilize firing rates. Here we show that homeostatic scaling of excitatory synapses is impaired in mouse hippocampal neurons lacking presenilin 1 (PS1(−/−)) or expressing a familial Alzheimer’s disease-linked PS1 mutation (PS1(M146V)). These findings suggest that deficits in synaptic homeostasis may contribute to brain dysfunction in Alzheimer’s disease.
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spelling pubmed-31649172012-03-01 Presenilin 1 Regulates Homeostatic Synaptic Scaling Through Akt Signaling Pratt, Kara G. Zimmerman, Eric C. Cook, David G. Sullivan, Jane M. Nat Neurosci Article Neurons in vivo and in vitro adapt to long-lasting changes in network activity by adjusting their synaptic strengths to stabilize firing rates. Here we show that homeostatic scaling of excitatory synapses is impaired in mouse hippocampal neurons lacking presenilin 1 (PS1(−/−)) or expressing a familial Alzheimer’s disease-linked PS1 mutation (PS1(M146V)). These findings suggest that deficits in synaptic homeostasis may contribute to brain dysfunction in Alzheimer’s disease. 2011-08-14 /pmc/articles/PMC3164917/ /pubmed/21841774 http://dx.doi.org/10.1038/nn.2893 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Pratt, Kara G.
Zimmerman, Eric C.
Cook, David G.
Sullivan, Jane M.
Presenilin 1 Regulates Homeostatic Synaptic Scaling Through Akt Signaling
title Presenilin 1 Regulates Homeostatic Synaptic Scaling Through Akt Signaling
title_full Presenilin 1 Regulates Homeostatic Synaptic Scaling Through Akt Signaling
title_fullStr Presenilin 1 Regulates Homeostatic Synaptic Scaling Through Akt Signaling
title_full_unstemmed Presenilin 1 Regulates Homeostatic Synaptic Scaling Through Akt Signaling
title_short Presenilin 1 Regulates Homeostatic Synaptic Scaling Through Akt Signaling
title_sort presenilin 1 regulates homeostatic synaptic scaling through akt signaling
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164917/
https://www.ncbi.nlm.nih.gov/pubmed/21841774
http://dx.doi.org/10.1038/nn.2893
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AT sullivanjanem presenilin1regulateshomeostaticsynapticscalingthroughaktsignaling

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