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Presenilin 1 Regulates Homeostatic Synaptic Scaling Through Akt Signaling
Neurons in vivo and in vitro adapt to long-lasting changes in network activity by adjusting their synaptic strengths to stabilize firing rates. Here we show that homeostatic scaling of excitatory synapses is impaired in mouse hippocampal neurons lacking presenilin 1 (PS1(−/−)) or expressing a famili...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164917/ https://www.ncbi.nlm.nih.gov/pubmed/21841774 http://dx.doi.org/10.1038/nn.2893 |