Harmonin inhibits presynaptic Ca(v)1.3 Ca(2+) channels in mouse inner hair cells

Harmonin is a scaffolding protein required for normal mechanosensory function in hair cells. Here, we describe a novel presynaptic association of harmonin and Ca(v)1.3 Ca(2+) channels at the mouse inner hair cell synapse, which limits channel availability through a ubiquitin-dependent pathway.

Detalles Bibliográficos
Autores principales: Gregory, Frederick D., Bryan, Keith E., Pangršič, Tina, Calin-Jageman, Irina E., Moser, Tobias, Lee, Amy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164920/
https://www.ncbi.nlm.nih.gov/pubmed/21822269
http://dx.doi.org/10.1038/nn.2895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164920/
https://www.ncbi.nlm.nih.gov/pubmed/21822269
http://dx.doi.org/10.1038/nn.2895

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