Harmonin inhibits presynaptic Ca(v)1.3 Ca(2+) channels in mouse inner hair cells

Harmonin is a scaffolding protein required for normal mechanosensory function in hair cells. Here, we describe a novel presynaptic association of harmonin and Ca(v)1.3 Ca(2+) channels at the mouse inner hair cell synapse, which limits channel availability through a ubiquitin-dependent pathway.

Detalles Bibliográficos
Autores principales: Gregory, Frederick D., Bryan, Keith E., Pangršič, Tina, Calin-Jageman, Irina E., Moser, Tobias, Lee, Amy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164920/
https://www.ncbi.nlm.nih.gov/pubmed/21822269
http://dx.doi.org/10.1038/nn.2895
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author Gregory, Frederick D.
Bryan, Keith E.
Pangršič, Tina
Calin-Jageman, Irina E.
Moser, Tobias
Lee, Amy
author_facet Gregory, Frederick D.
Bryan, Keith E.
Pangršič, Tina
Calin-Jageman, Irina E.
Moser, Tobias
Lee, Amy
author_sort Gregory, Frederick D.
collection PubMed
description Harmonin is a scaffolding protein required for normal mechanosensory function in hair cells. Here, we describe a novel presynaptic association of harmonin and Ca(v)1.3 Ca(2+) channels at the mouse inner hair cell synapse, which limits channel availability through a ubiquitin-dependent pathway.
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spelling pubmed-31649202012-03-01 Harmonin inhibits presynaptic Ca(v)1.3 Ca(2+) channels in mouse inner hair cells Gregory, Frederick D. Bryan, Keith E. Pangršič, Tina Calin-Jageman, Irina E. Moser, Tobias Lee, Amy Nat Neurosci Article Harmonin is a scaffolding protein required for normal mechanosensory function in hair cells. Here, we describe a novel presynaptic association of harmonin and Ca(v)1.3 Ca(2+) channels at the mouse inner hair cell synapse, which limits channel availability through a ubiquitin-dependent pathway. 2011-08-07 /pmc/articles/PMC3164920/ /pubmed/21822269 http://dx.doi.org/10.1038/nn.2895 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Gregory, Frederick D.
Bryan, Keith E.
Pangršič, Tina
Calin-Jageman, Irina E.
Moser, Tobias
Lee, Amy
Harmonin inhibits presynaptic Ca(v)1.3 Ca(2+) channels in mouse inner hair cells
title Harmonin inhibits presynaptic Ca(v)1.3 Ca(2+) channels in mouse inner hair cells
title_full Harmonin inhibits presynaptic Ca(v)1.3 Ca(2+) channels in mouse inner hair cells
title_fullStr Harmonin inhibits presynaptic Ca(v)1.3 Ca(2+) channels in mouse inner hair cells
title_full_unstemmed Harmonin inhibits presynaptic Ca(v)1.3 Ca(2+) channels in mouse inner hair cells
title_short Harmonin inhibits presynaptic Ca(v)1.3 Ca(2+) channels in mouse inner hair cells
title_sort harmonin inhibits presynaptic ca(v)1.3 ca(2+) channels in mouse inner hair cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164920/
https://www.ncbi.nlm.nih.gov/pubmed/21822269
http://dx.doi.org/10.1038/nn.2895
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AT calinjagemanirinae harmonininhibitspresynapticcav13ca2channelsinmouseinnerhaircells
AT mosertobias harmonininhibitspresynapticcav13ca2channelsinmouseinnerhaircells
AT leeamy harmonininhibitspresynapticcav13ca2channelsinmouseinnerhaircells

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