Conserved properties of human and bovine prion strains on transmission to guinea pigs

The first transmissions of human prion diseases to rodents used guinea pigs (Gps, Cavia porcellus). Later, transgenic (Tg) mice expressing human or chimeric human/mouse PrP replaced Gps, but the small size of the mouse limits some investigations. To investigate the fidelity of strain-specific prion...

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Detalles Bibliográficos
Autores principales: Safar, Jiri G., Giles, Kurt, Lessard, Pierre, Letessier, Frederic, Patel, Smita, Serban, Ana, DeArmond, Stephen J., Prusiner, Stanley B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164925/
https://www.ncbi.nlm.nih.gov/pubmed/21727894
http://dx.doi.org/10.1038/labinvest.2011.89

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164925/
https://www.ncbi.nlm.nih.gov/pubmed/21727894
http://dx.doi.org/10.1038/labinvest.2011.89

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