LIN28B fosters colon cancer migration, invasion, and transformation through let-7 dependent and independent mechanisms

Lin28b is an RNA-binding protein that inhibits biogenesis of let-7 microRNAs. LIN28B is overexpressed in diverse cancers, yet a specific role in the molecular pathogenesis of colon cancer has yet to be elucidated. We have determined that human colon tumors exhibit decreased levels of mature let-7 is...

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Detalles Bibliográficos
Autores principales: King, Catrina, Wang, Louise, Winograd, Rafael, Madison, Blair, Mongroo, Perry, Johnstone, Cameron, Rustgi, Anil K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165068/
https://www.ncbi.nlm.nih.gov/pubmed/21625210
http://dx.doi.org/10.1038/onc.2011.131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165068/
https://www.ncbi.nlm.nih.gov/pubmed/21625210
http://dx.doi.org/10.1038/onc.2011.131

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