Cargando…

LIN28B fosters colon cancer migration, invasion, and transformation through let-7 dependent and independent mechanisms

Lin28b is an RNA-binding protein that inhibits biogenesis of let-7 microRNAs. LIN28B is overexpressed in diverse cancers, yet a specific role in the molecular pathogenesis of colon cancer has yet to be elucidated. We have determined that human colon tumors exhibit decreased levels of mature let-7 is...

Descripción completa

Detalles Bibliográficos
Autores principales:	King, Catrina, Wang, Louise, Winograd, Rafael, Madison, Blair, Mongroo, Perry, Johnstone, Cameron, Rustgi, Anil K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165068/ https://www.ncbi.nlm.nih.gov/pubmed/21625210 http://dx.doi.org/10.1038/onc.2011.131

Ejemplares similares

LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7
por: Madison, Blair B., et al.
Publicado: (2013)

The LIN28/let-7 Pathway in Cancer
por: Balzeau, Julien, et al.
Publicado: (2017)

Oncogene Lin28B increases chemosensitivity of colon cancer cells in a let-7-independent manner
por: Ma, Lihong, et al.
Publicado: (2018)

Deregulation of MYCN, LIN28B and LET7 in a Molecular Subtype of Aggressive High-Grade Serous Ovarian Cancers
por: Helland, Åslaug, et al.
Publicado: (2011)

Comparison of the expression and function of Lin28A and Lin28B in colon cancer
por: Wang, Tianzhen, et al.
Publicado: (2016)

Lin28 and let-7 regulate the timing of cessation of murine nephrogenesis
por: Yermalovich, Alena V., et al.
Publicado: (2019)

LIN-10 can promote LET-23 EGFR signaling and trafficking independently of LIN-2 and LIN-7
por: Gauthier, Kimberley D., et al.
Publicado: (2021)

Correction: Comparison of the expression and function of Lin28A and Lin28B in colon cancer
por: Wang, Tianzhen, et al.
Publicado: (2021)

LIN28B induces a differentiation program through CDX2 in colon cancer
por: Suzuki, Kensuke, et al.
Publicado: (2021)

Aberrant regulation of the LIN28A/LIN28B and let-7 loop in human malignant tumors and its effects on the hallmarks of cancer
por: Wang, Tianzhen, et al.
Publicado: (2015)

The Lin28/let-7 axis is critical for myelination in the peripheral nervous system
por: Gökbuget, Deniz, et al.
Publicado: (2015)

LIN28B and Let-7 in Diffuse Midline Glioma: A Review
por: Knowles, Truman, et al.
Publicado: (2023)

Trophectoderm Transcriptome Analysis in LIN28 Knockdown Ovine Conceptuses Suggests Diverse Roles of the LIN28-let-7 Axis in Placental and Fetal Development
por: Ali, Asghar, et al.
Publicado: (2022)

The Lin28 cold-shock domain remodels pre-let-7 microRNA
por: Mayr, Florian, et al.
Publicado: (2012)

The Lin28/Let-7 System in Early Human Embryonic Tissue and Ectopic Pregnancy
por: Lozoya, Teresa, et al.
Publicado: (2014)

Bistable Switch in let-7 miRNA Biogenesis Pathway Involving Lin28
por: Shi, Fei, et al.
Publicado: (2014)

Control of neural crest multipotency by Wnt signaling and the Lin28/let-7 axis
por: Bhattacharya, Debadrita, et al.
Publicado: (2018)

The Role of LIN28-let-7-ARID3B Pathway in Placental Development
por: Ali, Asghar, et al.
Publicado: (2020)

Author Correction: Lin28 and let-7 regulate the timing of cessation of murine nephrogenesis
por: Yermalovich, Alena V., et al.
Publicado: (2020)

Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28
por: Wang, Longfei, et al.
Publicado: (2018)

A nanobody targeting the LIN28:let-7 interaction fragment of TUT4 blocks uridylation of let-7
por: Yu, Chunxiao, et al.
Publicado: (2020)

Mechanism of Dis3L2 substrate recognition in the Lin28/let-7 pathway
por: Faehnle, Christopher R., et al.
Publicado: (2014)

Metabolic Rescue of Obese Adipose-Derived Stem Cells by Lin28/Let7 Pathway
por: Pérez, Laura M., et al.
Publicado: (2013)

The LIN28B/let-7 axis is a novel therapeutic pathway in Multiple Myeloma
por: Manier, Salomon, et al.
Publicado: (2016)

Let-7, Lin28 and Hmga2 Expression in Ciliary Epithelium and Retinal Progenitor Cells
por: Frasson, Lorena Teixeira, et al.
Publicado: (2021)

LIN28B Promotes Colon Cancer Migration and Recurrence
por: Pang, Minghui, et al.
Publicado: (2014)

Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in embryonic stem cells
por: Hagan, John P., et al.
Publicado: (2009)

Stepwise assembly of multiple Lin28 proteins on the terminal loop of let-7 miRNA precursors
por: Desjardins, Alexandre, et al.
Publicado: (2014)

Targeting ornithine decarboxylase reverses the LIN28/Let-7 axis and inhibits glycolytic metabolism in neuroblastoma
por: Lozier, Ann M., et al.
Publicado: (2014)

A role of uridylation pathway for blockade of let-7 microRNA biogenesis by Lin28B
por: Suzuki, Hiroshi I, et al.
Publicado: (2015)

Developmental regulation of myeloerythroid progenitor function by the Lin28b–let-7–Hmga2 axis
por: Rowe, R. Grant, et al.
Publicado: (2016)

Crystal structure of the Lin28-interacting module of human terminal uridylyltransferase that regulates let-7 expression
por: Yamashita, Seisuke, et al.
Publicado: (2019)

Identification of small molecule inhibitors of the Lin28-mediated blockage of pre-let-7g processing
por: Lightfoot, Helen L., et al.
Publicado: (2016)

Trisubstituted Pyrrolinones as Small-Molecule Inhibitors Disrupting the Protein–RNA Interaction of LIN28 and Let-7
por: Borgelt, Lydia, et al.
Publicado: (2021)

The LIN28B–IMP1 post-transcriptional regulon has opposing effects on oncogenic signaling in the intestine
por: Chatterji, Priya, et al.
Publicado: (2018)

Importance of the NCp7-like domain in the recognition of pre-let-7g by the pluripotency factor Lin28
por: Desjardins, Alexandre, et al.
Publicado: (2012)

LIN-28 co-transcriptionally binds primary let-7 to regulate miRNA maturation in C. elegans
por: Van Wynsberghe, Priscilla M., et al.
Publicado: (2011)

A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway
por: Chang, Hao-Ming, et al.
Publicado: (2013)

TRIM71 suppresses tumorigenesis via modulation of Lin28B-let-7-HMGA2 signaling
por: Yin, Jinlong, et al.
Publicado: (2016)

SUMOylation modulates the LIN28A‐let‐7 signaling pathway in response to cellular stresses in cancer cells
por: Dou, Jinzhuo, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ambhavefuu1q9se6vn8ehl5515