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Redundancy and specificity of the metalloprotease system mediating oncogenic NOTCH1 activation in T-ALL
Oncogenic mutations in NOTCH1 are present in over 50% of T-cell lymphoblastic leukemias (T-ALLs). Activation of NOTCH1 requires a double proteolytic processing in the extracellular region of the receptor (S2) and in the transmembrane domain (S3). Currently, anti-NOTCH1 therapies based on inhibition...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165074/ https://www.ncbi.nlm.nih.gov/pubmed/21625236 http://dx.doi.org/10.1038/leu.2011.130 |