Targeting Epigenetic Regulation of miR-34a for Treatment of Pancreatic Cancer by Inhibition of Pancreatic Cancer Stem Cells

BACKGROUND: MicroRNA-34a (miR-34a) is a transcriptional target of p53 and is down-regulated in pancreatic cancer. This study aimed to investigate the functional significance of miR-34a in pancreatic cancer progression through its epigenetic restoration with chromatin modulators, demethylating agent...

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Detalles Bibliográficos
Autores principales: Nalls, Dara, Tang, Su-Ni, Rodova, Marianna, Srivastava, Rakesh K., Shankar, Sharmila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166078/
https://www.ncbi.nlm.nih.gov/pubmed/21909380
http://dx.doi.org/10.1371/journal.pone.0024099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166078/
https://www.ncbi.nlm.nih.gov/pubmed/21909380
http://dx.doi.org/10.1371/journal.pone.0024099

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