High-Content Chemical and RNAi Screens for Suppressors of Neurotoxicity in a Huntington's Disease Model

To identify Huntington's Disease therapeutics, we conducted high-content small molecule and RNAi suppressor screens using a Drosophila primary neural culture Huntingtin model. Drosophila primary neurons offer a sensitive readout for neurotoxicty, as their neurites develop dysmorphic features in...

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Detalles Bibliográficos
Autores principales: Schulte, Joost, Sepp, Katharine J., Wu, Chaohong, Hong, Pengyu, Littleton, J. Troy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166080/
https://www.ncbi.nlm.nih.gov/pubmed/21909362
http://dx.doi.org/10.1371/journal.pone.0023841

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166080/
https://www.ncbi.nlm.nih.gov/pubmed/21909362
http://dx.doi.org/10.1371/journal.pone.0023841

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