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High-Content Chemical and RNAi Screens for Suppressors of Neurotoxicity in a Huntington's Disease Model
To identify Huntington's Disease therapeutics, we conducted high-content small molecule and RNAi suppressor screens using a Drosophila primary neural culture Huntingtin model. Drosophila primary neurons offer a sensitive readout for neurotoxicty, as their neurites develop dysmorphic features in...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166080/ https://www.ncbi.nlm.nih.gov/pubmed/21909362 http://dx.doi.org/10.1371/journal.pone.0023841 |