Identification of Novel Functional Inhibitors of Acid Sphingomyelinase

We describe a hitherto unknown feature for 27 small drug-like molecules, namely functional inhibition of acid sphingomyelinase (ASM). These entities named FIASMAs (Functional Inhibitors of Acid SphingoMyelinAse), therefore, can be potentially used to treat diseases associated with enhanced activity...

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Detalles Bibliográficos
Autores principales: Kornhuber, Johannes, Muehlbacher, Markus, Trapp, Stefan, Pechmann, Stefanie, Friedl, Astrid, Reichel, Martin, Mühle, Christiane, Terfloth, Lothar, Groemer, Teja W., Spitzer, Gudrun M., Liedl, Klaus R., Gulbins, Erich, Tripal, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166082/
https://www.ncbi.nlm.nih.gov/pubmed/21909365
http://dx.doi.org/10.1371/journal.pone.0023852

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166082/
https://www.ncbi.nlm.nih.gov/pubmed/21909365
http://dx.doi.org/10.1371/journal.pone.0023852

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