Cargando…

Identification of Novel Functional Inhibitors of Acid Sphingomyelinase

We describe a hitherto unknown feature for 27 small drug-like molecules, namely functional inhibition of acid sphingomyelinase (ASM). These entities named FIASMAs (Functional Inhibitors of Acid SphingoMyelinAse), therefore, can be potentially used to treat diseases associated with enhanced activity...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kornhuber, Johannes, Muehlbacher, Markus, Trapp, Stefan, Pechmann, Stefanie, Friedl, Astrid, Reichel, Martin, Mühle, Christiane, Terfloth, Lothar, Groemer, Teja W., Spitzer, Gudrun M., Liedl, Klaus R., Gulbins, Erich, Tripal, Philipp
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166082/ https://www.ncbi.nlm.nih.gov/pubmed/21909365 http://dx.doi.org/10.1371/journal.pone.0023852

Ejemplares similares

Functional Implications of Novel Human Acid Sphingomyelinase Splice Variants
por: Rhein, Cosima, et al.
Publicado: (2012)

Characterization of Acid Sphingomyelinase Activity in Human Cerebrospinal Fluid
por: Mühle, Christiane, et al.
Publicado: (2013)

Role of Acid Sphingomyelinase in the Regulation of Social Behavior and Memory
por: Zoicas, Iulia, et al.
Publicado: (2016)

Peripheral Acid Sphingomyelinase Activity Is Associated with Biomarkers and Phenotypes of Alcohol Use and Dependence in Patients and Healthy Controls
por: Mühle, Christiane, et al.
Publicado: (2018)

Secretory Acid Sphingomyelinase in the Serum of Medicated Patients Predicts the Prospective Course of Depression
por: Mühle, Christiane, et al.
Publicado: (2019)

Qualitative prediction of blood–brain barrier permeability on a large and refined dataset
por: Muehlbacher, Markus, et al.
Publicado: (2011)

The acid sphingomyelinase/ceramide system in COVID-19
por: Kornhuber, Johannes, et al.
Publicado: (2021)

mRNA Expression of SMPD1 Encoding Acid Sphingomyelinase Decreases upon Antidepressant Treatment
por: Rhein, Cosima, et al.
Publicado: (2021)

Characterization of a Neutral Sphingomyelinase Activity in Human Serum and Plasma
por: Mühle, Christiane, et al.
Publicado: (2023)

The Forebrain-Specific Overexpression of Acid Sphingomyelinase Induces Depressive-Like Symptoms in Mice
por: Zoicas, Iulia, et al.
Publicado: (2020)

Identification of Drugs Inducing Phospholipidosis by Novel in vitro Data
por: Muehlbacher, Markus, et al.
Publicado: (2012)

Enhanced Alcohol Preference and Anxiolytic Alcohol Effects in Niemann-Pick Disease Model in Mice
por: Kalinichenko, Liubov S., et al.
Publicado: (2019)

Paradoxical antidepressant effects of alcohol are related to acid sphingomyelinase and its control of sphingolipid homeostasis
por: Müller, Christian P., et al.
Publicado: (2016)

Chronic Psychosocial Stress in Mice Is Associated With Increased Acid Sphingomyelinase Activity in Liver and Serum and With Hepatic C16:0-Ceramide Accumulation
por: Reichel, Martin, et al.
Publicado: (2018)

Anxiety and Depression Are Related to Higher Activity of Sphingolipid Metabolizing Enzymes in the Rat Brain
por: Zoicas, Iulia, et al.
Publicado: (2020)

Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cells
por: Carpinteiro, Alexander, et al.
Publicado: (2021)

Alleged Detrimental Mutations in the SMPD1 Gene in Patients with Niemann-Pick Disease
por: Rhein, Cosima, et al.
Publicado: (2015)

Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons
por: Beckmann, Nadine, et al.
Publicado: (2014)

Acid Sphingomyelinase Is a Modulator of Contextual Fear
por: Zoicas, Iulia, et al.
Publicado: (2022)

Common strength and localization of spontaneous and evoked synaptic vesicle release sites
por: Loy, Kristina, et al.
Publicado: (2014)

Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells
por: Carpinteiro, Alexander, et al.
Publicado: (2020)

Repurposing antidepressants inhibiting the sphingomyelinase acid/ceramide system against COVID-19: current evidence and potential mechanisms
por: Hoertel, Nicolas, et al.
Publicado: (2021)

Acid sphingomyelinase deficiency enhances myelin repair after acute and chronic demyelination
por: Chami, Marwan, et al.
Publicado: (2017)

New Molecular Targets for Antidepressant Drugs
por: Kornhuber, Johannes, et al.
Publicado: (2021)

DC-SIGN Mediated Sphingomyelinase-Activation and Ceramide Generation Is Essential for Enhancement of Viral Uptake in Dendritic Cells
por: Avota, Elita, et al.
Publicado: (2011)

Stress induces major depressive disorder by a neutral sphingomyelinase 2-mediated accumulation of ceramide-enriched exosomes in the blood plasma
por: Schumacher, Fabian, et al.
Publicado: (2022)

Acid Sphingomyelinase Deficiency Ameliorates Farber Disease
por: Beckmann, Nadine, et al.
Publicado: (2019)

Acid Sphingomyelinase Inhibition Prevents Hemolysis During Erythrocyte Storage
por: Hoehn, Richard S., et al.
Publicado: (2016)

Common network effect-patterns after monoamine reuptake inhibition in dissociated hippocampus cultures
por: Trepl, Julia, et al.
Publicado: (2022)

Correction to: Common network effect‑patterns after monoamine reuptake inhibition in dissociated hippocampus cultures
por: Trepl, Julia, et al.
Publicado: (2022)

Medications Modulating the Acid Sphingomyelinase/Ceramide System and 28-Day Mortality among Patients with SARS-CoV-2: An Observational Study
por: Hoertel, Nicolas, et al.
Publicado: (2023)

Regulation of hematogenous tumor metastasis by acid sphingomyelinase
por: Carpinteiro, Alexander, et al.
Publicado: (2015)

Differential Activation of Acid Sphingomyelinase and Ceramide Release Determines Invasiveness of Neisseria meningitidis into Brain Endothelial Cells
por: Simonis, Alexander, et al.
Publicado: (2014)

Acid sphingomyelinase expression is associated with survival in resectable pancreatic ductal adenocarcinoma
por: Wilson, Gregory C., et al.
Publicado: (2023)

Neutral ceramidase is a marker for cognitive performance in rats and monkeys
por: Kalinichenko, Liubov S., et al.
Publicado: (2020)

Acid sphingomyelinase promotes SGK1-dependent vascular calcification
por: Luong, Trang Thi Doan, et al.
Publicado: (2021)

Feasibility and Diagnostic Accuracy of Ischemic Stroke Territory Recognition Based on Two-Dimensional Projections of Three-Dimensional Diffusion MRI Data
por: Wrosch, Jana Katharina, et al.
Publicado: (2015)

Corrigendum: Feasibility and Diagnostic Accuracy of Ischemic Stroke Territory Recognition Based on Two-dimensional Projections of Three-dimensional Diffusion MRI Data
por: Wrosch, Jana Katharina, et al.
Publicado: (2017)

Tonic Control of Secretory Acid Sphingomyelinase Over Ventral Hippocampal Synaptic Transmission and Neuron Excitability
por: Lin, Chih-Hung, et al.
Publicado: (2021)

Statistical methods for detecting and comparing periodic data and their application to the nycthemeral rhythm of bodily harm: A population based study
por: Stroebel, Armin M, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_1opiihnjb0en1ku3s3dc6s4q3q