Osteopontin Enhances the Expression and Activity of MMP-2 via the SDF-1/CXCR4 Axis in Hepatocellular Carcinoma Cell Lines

BACKGROUND AND AIMS: Osteopontin, SDF-1α, and MMP-2 are important secreted molecules involved in the pathophysiology of human hepatocellular carcinoma (HCC). This study investigates the effect of the SDF-1α/CXCR4 axis on expression and activity of MMP-2 induced by osteopontin. METHODS: The expressio...

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Detalles Bibliográficos
Autores principales: Zhang, Rihua, Pan, Xiaolin, Huang, Zuhu, Weber, Georg F., Zhang, Guoxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166084/
https://www.ncbi.nlm.nih.gov/pubmed/21909361
http://dx.doi.org/10.1371/journal.pone.0023831

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166084/
https://www.ncbi.nlm.nih.gov/pubmed/21909361
http://dx.doi.org/10.1371/journal.pone.0023831

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