Testing the FMR1 Promoter for Mosaicism in DNA Methylation among CpG Sites, Strands, and Cells in FMR1-Expressing Males with Fragile X Syndrome

Variability among individuals in the severity of fragile X syndrome (FXS) is influenced by epigenetic methylation mosaicism, which may also be common in other complex disorders. The epigenetic signal of dense promoter DNA methylation is usually associated with gene silencing, as was initially report...

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Detalles Bibliográficos
Autores principales: Stöger, Reinhard, Genereux, Diane P., Hagerman, Randi J., Hagerman, Paul J., Tassone, Flora, Laird, Charles D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166088/
https://www.ncbi.nlm.nih.gov/pubmed/21909353
http://dx.doi.org/10.1371/journal.pone.0023648

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166088/
https://www.ncbi.nlm.nih.gov/pubmed/21909353
http://dx.doi.org/10.1371/journal.pone.0023648

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