Sprouty 2 Is an Independent Prognostic Factor in Breast Cancer and May Be Useful in Stratifying Patients for Trastuzumab Therapy

BACKGROUND: Resistance to trastuzumab is a clinical problem, partly due to overriding activation of MAPK/PI3K signalling. Sprouty-family proteins are negative regulators of MAPK/PI3K signalling, but their role in HER2-therapy resistance is unknown. PATIENTS AND METHODS: Associations between Sprouty...

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Detalles Bibliográficos
Autores principales: Faratian, Dana, Sims, Andrew H., Mullen, Peter, Kay, Charlene, Um, InHwa, Langdon, Simon P., Harrison, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166119/
https://www.ncbi.nlm.nih.gov/pubmed/21909357
http://dx.doi.org/10.1371/journal.pone.0023772

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166119/
https://www.ncbi.nlm.nih.gov/pubmed/21909357
http://dx.doi.org/10.1371/journal.pone.0023772

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