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Sprouty 2 Is an Independent Prognostic Factor in Breast Cancer and May Be Useful in Stratifying Patients for Trastuzumab Therapy

BACKGROUND: Resistance to trastuzumab is a clinical problem, partly due to overriding activation of MAPK/PI3K signalling. Sprouty-family proteins are negative regulators of MAPK/PI3K signalling, but their role in HER2-therapy resistance is unknown. PATIENTS AND METHODS: Associations between Sprouty...

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Detalles Bibliográficos
Autores principales:	Faratian, Dana, Sims, Andrew H., Mullen, Peter, Kay, Charlene, Um, InHwa, Langdon, Simon P., Harrison, David J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166119/ https://www.ncbi.nlm.nih.gov/pubmed/21909357 http://dx.doi.org/10.1371/journal.pone.0023772

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