Inhibition of Lipoprotein-Associated Phospholipase A2 Ameliorates Inflammation and Decreases Atherosclerotic Plaque Formation in ApoE-Deficient Mice

BACKGROUND: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is thought to play modulatory roles in the development of atherosclerosis. Here we evaluated the effects of a specific lp-PLA2 inhibitor on atherosclerosis in ApoE-deficient mice and its associated mechanisms. METHODOLOGY/PRINCIPAL FINDIN...

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Detalles Bibliográficos
Autores principales: Wang, Wen-yi, Zhang, Jie, Wu, Wen-yu, Li, Jie, Ma, Yan-ling, Chen, Wei-hai, Yan, Hong, Wang, Kai, Xu, Wen-wei, Shen, Jian-hua, Wang, Yi-ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166130/
https://www.ncbi.nlm.nih.gov/pubmed/21909350
http://dx.doi.org/10.1371/journal.pone.0023425

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166130/
https://www.ncbi.nlm.nih.gov/pubmed/21909350
http://dx.doi.org/10.1371/journal.pone.0023425

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