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Evaluation of Two Models for Human Topoisomerase I Interaction with dsDNA and Camptothecin Derivatives
Human topoisomerase I (Top1) relaxes supercoiled DNA during cell division. Camptothecin stabilizes Top1/dsDNA covalent complexes which ultimately results in cell death, and this makes Top1 an anti-cancer target. There are two current models for how camptothecin and derivatives bind to Top1/dsDNA cov...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166174/ https://www.ncbi.nlm.nih.gov/pubmed/21912628 http://dx.doi.org/10.1371/journal.pone.0024314 |